Effects of deep brain stimulation and medication on strength, bradykinesia, and electromyographic patterns of the ankle joint in Parkinson's disease
Identifieur interne : 003459 ( Main/Exploration ); précédent : 003458; suivant : 003460Effects of deep brain stimulation and medication on strength, bradykinesia, and electromyographic patterns of the ankle joint in Parkinson's disease
Auteurs : David E. Vaillancourt [États-Unis] ; Janey Prodoehl [États-Unis] ; Molly M. Sturman [États-Unis] ; Roy A. E. Bakay [États-Unis] ; Leo Verhagen Metman [États-Unis] ; Daniel M. Corcos [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-01.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Ankle Joint (innervation), Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Biomechanical Phenomena, Carbidopa (administration & dosage), Carbidopa (adverse effects), Chemotherapy, Combined Modality Therapy, Deep Brain Stimulation (methods), Deep brain stimulation, Electrodes, Implanted, Electromyography, Electromyography (drug effects), Humans, Hypokinesia (physiopathology), Hypokinesia (therapy), Isometric Contraction (drug effects), Isometric Contraction (physiology), Joint, Levodopa (administration & dosage), Levodopa (adverse effects), Muscle Weakness (physiopathology), Muscle Weakness (therapy), Muscle, Skeletal (innervation), Nervous system diseases, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Reference Values, Signal Processing, Computer-Assisted, Statistics as Topic, Strength, Subthalamic nucleus, Torque, Treatment Outcome, Tremor, Tremor (physiopathology), Tremor (therapy), bradykinesia, deep brain stimulation, electromyography, subthalamic nucleus, tremor.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Carbidopa, Levodopa.
- chemical , adverse effects : Antiparkinson Agents, Carbidopa, Levodopa.
- diagnosis : Parkinson Disease.
- drug effects : Electromyography, Isometric Contraction.
- innervation : Ankle Joint, Muscle, Skeletal.
- methods : Deep Brain Stimulation.
- physiology : Isometric Contraction.
- physiopathology : Hypokinesia, Muscle Weakness, Parkinson Disease, Tremor.
- therapy : Hypokinesia, Muscle Weakness, Parkinson Disease, Tremor.
- Biomechanical Phenomena, Combined Modality Therapy, Electrodes, Implanted, Humans, Reference Values, Signal Processing, Computer-Assisted, Statistics as Topic, Torque, Treatment Outcome.
Abstract
We investigated the control of movement in 12 patients with Parkinson's disease (PD) after they received surgically implanted high‐frequency stimulating electrodes in the subthalamic nucleus (STN). The experiment studied ankle strength, movement velocity, and the associated electromyographic patterns in PD patients, six of whom had tremor at the ankle. The patients were studied off treatment, ON STN deep brain stimulation (DBS), on medication, and on medication plus STN DBS. Twelve matched control subjects were also examined. Medication alone and STN DBS alone increased patients' ankle strength, ankle velocity, agonist muscle burst amplitude, and agonist burst duration, while reducing the number of agonist bursts during movement. These findings were similar for PD patients with and without tremor. The combination of medication plus STN DBS normalized maximal strength at the ankle joint, but ankle movement velocity and electromyographic patterns were not normalized. The findings are the first to demonstrate that STN DBS and medication increase strength and movement velocity at the ankle joint. © 2005 Movement Disorder Society
Url:
- https://api.istex.fr/document/5E8229A6329B59462BDEE99280CBA6B770ECC503/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373255
DOI: 10.1002/mds.20672
Affiliations:
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Bakay</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, Rush Presbyterian–St. Luke's Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush Presbyterian–St. Luke's Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-01">2006-01</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="50">50</biblScope><biblScope unit="page" to="58">58</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5E8229A6329B59462BDEE99280CBA6B770ECC503</idno><idno type="DOI">10.1002/mds.20672</idno><idno type="ArticleID">MDS20672</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ankle Joint (innervation)</term><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (adverse effects)</term><term>Biomechanical Phenomena</term><term>Carbidopa (administration & dosage)</term><term>Carbidopa (adverse effects)</term><term>Chemotherapy</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation (methods)</term><term>Deep brain stimulation</term><term>Electrodes, Implanted</term><term>Electromyography</term><term>Electromyography (drug effects)</term><term>Humans</term><term>Hypokinesia (physiopathology)</term><term>Hypokinesia (therapy)</term><term>Isometric Contraction (drug effects)</term><term>Isometric Contraction (physiology)</term><term>Joint</term><term>Levodopa (administration & dosage)</term><term>Levodopa (adverse effects)</term><term>Muscle Weakness (physiopathology)</term><term>Muscle Weakness (therapy)</term><term>Muscle, Skeletal (innervation)</term><term>Nervous system diseases</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Reference Values</term><term>Signal Processing, Computer-Assisted</term><term>Statistics as Topic</term><term>Strength</term><term>Subthalamic nucleus</term><term>Torque</term><term>Treatment Outcome</term><term>Tremor</term><term>Tremor (physiopathology)</term><term>Tremor (therapy)</term><term>bradykinesia</term><term>deep brain stimulation</term><term>electromyography</term><term>subthalamic nucleus</term><term>tremor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>Carbidopa</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Carbidopa</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Electromyography</term><term>Isometric Contraction</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Ankle Joint</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Isometric Contraction</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypokinesia</term><term>Muscle Weakness</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Hypokinesia</term><term>Muscle Weakness</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biomechanical Phenomena</term><term>Combined Modality Therapy</term><term>Electrodes, Implanted</term><term>Humans</term><term>Reference Values</term><term>Signal Processing, Computer-Assisted</term><term>Statistics as Topic</term><term>Torque</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Articulation</term><term>Chimiothérapie</term><term>Electromyographie</term><term>Noyau sousthalamique</term><term>Parkinson maladie</term><term>Résistance mécanique</term><term>Stimulation cérébrale profonde</term><term>Système nerveux pathologie</term><term>Tremblement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the control of movement in 12 patients with Parkinson's disease (PD) after they received surgically implanted high‐frequency stimulating electrodes in the subthalamic nucleus (STN). The experiment studied ankle strength, movement velocity, and the associated electromyographic patterns in PD patients, six of whom had tremor at the ankle. The patients were studied off treatment, ON STN deep brain stimulation (DBS), on medication, and on medication plus STN DBS. Twelve matched control subjects were also examined. Medication alone and STN DBS alone increased patients' ankle strength, ankle velocity, agonist muscle burst amplitude, and agonist burst duration, while reducing the number of agonist bursts during movement. These findings were similar for PD patients with and without tremor. The combination of medication plus STN DBS normalized maximal strength at the ankle joint, but ankle movement velocity and electromyographic patterns were not normalized. The findings are the first to demonstrate that STN DBS and medication increase strength and movement velocity at the ankle joint. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name></region><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A. E." last="Bakay">Roy A. E. Bakay</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name><name sortKey="Prodoehl, Janey" sort="Prodoehl, Janey" uniqKey="Prodoehl J" first="Janey" last="Prodoehl">Janey Prodoehl</name><name sortKey="Sturman, Molly M" sort="Sturman, Molly M" uniqKey="Sturman M" first="Molly M." last="Sturman">Molly M. Sturman</name><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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